論文発表

【コメント】朝山が責任著者の発表論文のみ記載 *は責任著者

2018
S. Asayama*, K. Nagashima, Y. Negishi, H. Kawakami, By-Product-Free Intact Modification of Insulin by Cholesterol End-Modified Poly(ethylene glycol) for In Vivo Protein Delivery,Bioconjugate Chemistry, 29, 67-73 (2018).
DOI: 10.1021/acs.bioconjchem.7b00593
2017
S. Asayama*, K. Nagashima, H. Kawakami, Facile Method of Protein PEGylation by a Mono-Ion Complex,      ACS Omega, 2, 2382-2386 (2017).
DOI: 10.1021/acsomega.7b00462

S. Asayama*, M. Sakata, H. Kawakami, Structure-Activity Relationship between Zn2+-Chelated Alkylated Poly(1-vinylimidazole) and Gene Transfection,Journal of Inorganic Biochemistry, 173, 120-125 (2017).
DOI: 10.1016/j.jinorgbio.2017.05.007
2016
Y. Asaba, S. Asayama*, H. Kawakami*, Design of Epigenetics Control Carrier for Simultaneous Transfection of Histone Acetyltransferase with Histone Deacetylase Inhibitor to Continuous Histone Acetylation,Polymer Journal, 48, 561-564 (2016).
2015
S. Asayama*, A. Nohara, Y. Negishi, H. Kawakami, Plasmid DNA Mono-Ion Complex Stabilized by Hydrogen Bond for In Vivo Diffusive Gene Delivery,Biomacromolecules, 16, 1226-1231 (2015).

S. Asayama*, T. Kumagai, H. Kawakami, Screening for Methylated Poly(L-histidine) with Various Dimethylimidazolium/Methylimidazole/Imidazole Contents as DNA Carrier,Pharmaceutics, 7, 224-232 (2015).
2014
S. Asayama*, A. Nohara, Y. Negishi, H. Kawakami, Alkylimidazolium End-Modified Poly(ethylene glycol) to Form the Mono-Ion Complex with Plasmid DNA for In Vivo Gene Delivery,Biomacromolecules, 15, 997-1001 (2014).

S. Asayama*, K. Matsuda, Y. Negishi, H. Kawakami, Intracellular Co-Delivery of Zinc Ions and Plasmid DNA for Enhancing Gene Transfection Activity,Metallomics, 6, 82-87 (2014) (Selected for Inside Front Cover).

S. Asayama*, T. Hakamatani, H. Kawakami, Tuning of the Methylimidazolium/Imidazole Balance in Polycations for Gene Carrier,Polymers for Advanced Technologies, 25, 823-826 (2014).

R. Kubota, S. Asayama*, H. Kawakami*, A Bioinspired Polymer-Bound Mn-Porphyrins with an Artificial Active Center of Catalase,Chemical Communications, 50, 15909-15912 (2014).
2013
S. Asayama*, K. Seno, H. Kawakami, Synthesis of Carboxymethyl Poly(1-vinylimidazole) as a Polyampholyte for Biocompatibility,Chemistry Letters, 42, 358-360 (2013).
2012
S. Asayama*, T. Kumagai, H. Kawakami, Synthesis and Characterization of Methylated Poly(L-histidine) to Control the Stability of its siRNA Polyion Complexes for RNAi,Bioconjugate Chemistry, 23, 1437-1442 (2012).

K. Hazama, S. Asayama*, H. Kawakami*, Up-Regulation of Gene Expression by Transfection to Hepatocyte Spheroids,Molecular Pharmaceutics, 9, 3602-3605 (2012).

S. Asayama*, N. Hayakawa, H. Kawakami, Design of Mn-Porphyrin/Hyaluronic Acid Complexes for a Functional Antioxidant, ALA-Porphyrin Science , 1, 3-9 (2012).
2011
S. Asayama*, S. Nishinohara, H. Kawakami, Zinc-Chelated Poly(1-vinylimidazole) and a Carbohydrate Ligand Polycation Form DNA Ternary Complexes for Gene Delivery,Bioconjugate Chemistry, 22, 1864-1868 (2011).

S. Asayama*, S. Nishinohara, H. Kawakami, Zinc-Chelated Imidazole Groups for DNA Polyion Complex Formation,Metallomics, 3, 680-682 (2011).
2010
S. Asayama*, T. Hakamatani, H. Kawakami, Synthesis and Characterization of Alkylated Poly(1-vinylimidazole) to Control the Stability of its DNA Polyion Complexes for Gene Delivery,Bioconjugate Chemistry, 21, 646-652 (2010).
2008
S. Asayama*, A. Ogawa, H. Kawakami, S. Nagaoka, Double-Stranded RNA Homopolymer Poly(rC)∙Poly(rG) for a New pH-Sensitive Drug Carrier,Molecular Pharmaceutics, 5, 162-164 (2008).

S. Asayama*, M. Sudo, S. Nagaoka, H. Kawakami, Carboxymethyl Poly(L-histidine) as a New pH-Sensitive Poly- peptide to Enhance Polyplex Gene Delivery,Molecular Pharmaceutics, 5, 898-901 (2008).
2007
S. Asayama*, T. Sekine, H. Kawakami, S. Nagaoka, Design of Aminated Poly(1-vinylimidazole) for a New pH- Sensitive Polycation to Enhance Cell-Specific Gene Delivery,Bioconjugate Chemistry, 18, 1662-1667 (2007).

S. Asayama*, H. Kato, H. Kawakami, S. Nagaoka, Carboxymethyl Poly(L-histidine) as a New pH-Sensitive Poly- peptide at Endosomal/Lysosomal pH, Polymers for Advanced Technologies , 18, 329-333 (2007).
2006
S. Asayama*, T. Sekine, H. Kawakami, S. Nagaoka, pH-Dependent Dissociation of Carbohydrate Ligand Polycations from DNA Ternary Complexes, Chemistry Letters, 35, 100-101 (2006)

S. Asayama*, E. Kawamura, S. Nagaoka, H. Kawakami, Design of Manganese Porphyrin Modified with Mitochondrial Signal Peptide for a New Antioxidant,Molecular Pharmaceutics, 3, 468-470 (2006).
2005
S. Asayama*, T. Sekine, A. Hamaya, H. Kawakami, S. Nagaoka, Poly(L-histidine) with Several Aminoethyl Groups for a New pH-Sensitive DNA Carrier,Polymers for Advanced Technologies, 16, 567-570 (2005).
2004
S. Asayama*, H. Kawakami, S. Nagaoka, Design of the Poly(L-histidine)-Carbohydrate Conjugate for a New pH-Sensitive Drug Carrier,Polymers for Advanced Technologies, 15, 439-444 (2004).

S. Asayama*, K. Mizushima, S. Nagaoka, H. Kawakami, Design of Metalloporphyrin-Carbohydrate Conjugates for a New Superoxide Dismutase Mimic with Cellular Recognition,Bioconjugate Chemistry, 15, 1360-1363 (2004).
2003
S. Asayama*, H. Kawakami, S. Nagaoka, Facile Chemical Modification of the Poly(L-histidine) for a New pH-Sensitive Polypeptide,Chemistry Letters, 32, 1152-1153 (2003).