Epigenetics is a gene expression control structure to come from the chromatin
structure without the change of the DNA base sequence.
Epigenetic features, composed of multiple chromatin marks, may be maintained
after cellular division.
A large body of evidence suggests that the epigenome is inappropriately
altered in many human diseases, including most cancers and lifestyle disease.
Therefore, unlike genetic mutations, the ability having reversibility to
reprogram the epigenetic landscape is one of the most promising target
therapies.
So, we research to engineer epigenetics during tumorigenesis and enable
appropriate gene expression activity and control even exosomes secreted
by tumor cells.