論文発表

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2024
R. Misaizu, Y.Negishi, and S. Asayama*, Synthesis of N-oxide Poly(1-vinylimidazole) for pDNA Delivery Systems In Vivo, Chemistry Letters, 34, accepted.
DOI:
2023
R. Kon and S. Asayama*, Synthesis of Guanidinium-Dendrimer-Type pDNA Carriers for Gene Delivery into Floating Blood Cells, Polymers for Advanced Technologies, 34，3289-3295(2023).
DOI:10.1002/pat.6136
2022
Y. Kobayashi and S. Asayama*, Design of the Zinc Ion and Plasmid DNA Co-Delivery System by Poly(1-vinylimidazole) Derivatives for Myoblast Differentiation, ACS Applied Bio Materials, 5, 5754-5761 (2022).
DOI: 10.1021/acsabm.2c00737

R. Kimura, K. Nirasawa, Y. Negishi, and S. Asayama*, Tunable Gene Expression in Skeletal Muscles by the Molecular Weight of PEG Chain Length of Plasmid DNA Mono-Ion Complexes, Chemistry Letters, 51, 840-843 (2022).
DOI: org/10.1246/cl.220242

H. Qiao and S. Asayama*, Guanidinopropyl End-Modified Poly(ethylene glycol) to Form Highly Compact Plasmid DNA Mono-Ion Complexes by Thermal Treatment, Polymers for Advanced Technologies, 33, 484-491 (2022).
DOI: 10.1002/pat.5530
2021
A. Endo and S. Asayama*, Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization, Pharmaceutics, 13, 2084-2093 (2021).
DOI: 10.3390/pharmaceutics13012084

A. Mori, Y. Kobayashi, K. Nirasawa, Y. Negishi, and S. Asayama*, Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection, Pharmaceutics, 13, 78-88 (2021).
DOI: 10.3390/pharmaceutics13010078

Y. Kobayashi, K. Nirasawa, Y. Negishi, and S. Asayama*, Noncorrelative Relation between In Vitro and In Vivo for Plasmid DNA Transfection by Succinylated Polyethylenimine Muscular Injection, Journal of Biomaterials Science, Polymer Edition, 32, 405-416 (2021).
DOI: 10.1080/09205063.2020.1838045
2020
Y. Sone, M. Nogawa, and S. Asayama*, Designing a Bioinert Surface by Simple Coating with Cholesterol End- Modified Poly(ethylene glycol), Langmuir, 36, 12045-12052 (2020).
DOI: 10.1021/acs.langmuir.0c02481

A. Endo, T. Nagakura, H. Kawakami, and S. Asayama*, Synthesis and Characterization of Lactosylated Poly(1-vinylimidazole) for Cell-Specific Plasmid DNA Carrier, Internal Medicine and Care, 4, 1-5 (2020).
DOI:10.15761/IMC.1000136

S. Asayama*, Molecular Design of Polymer-Based Carriers for Plasmid DNA Delivery in Vitro and in Vivo (Highlight Review, Invite Only), Chemistry Letters, 49, 1-9 (2020).
DOI: 10.1246/cl.190696
2019
A. Endo and S. Asayama*, Preparation of Zn2+-Chelated Carboxymethyl Poly(1-vinylimidazole) for Intracellular Zn2+ Delivery, Journal of Minerals and Materials Characterization and Engineering,7, 213-220 (2019).
DOI: 10.4236/jmmce.2019.75016

Y. Kobayashi, S. Taneichi, H. Kawakami, Y. Negishi, and S. Asayama*, Plasmid DNA Mono-Ion Complex for In Vivo Sustainable Gene Expression,ACS Omega, 4,11464-11471 (2019).
DOI: 10.1021/acsomega.9b01323
2018
S. Asayama*, K. Nagashima, Y. Negishi, and H. Kawakami, By-Product-Free Intact Modification of Insulin by Cholesterol End-Modified Poly(ethylene glycol) for In Vivo Protein Delivery,Bioconjugate Chemistry,29, 67-73 (2018).
DOI: 10.1021/acs.bioconjchem.7b00593
2017
S. Asayama*, K. Nagashima, and H. Kawakami, Facile Method of Protein PEGylation by a Mono-Ion Complex,ACS Omega,2, 2382-2386 (2017).
DOI: 10.1021/acsomega.7b00462

S. Asayama*, M. Sakata, and H. Kawakami, Structure-Activity Relationship between Zn2+-Chelated Alkylated Poly(1-vinylimidazole) and Gene Transfection,Journal of Inorganic Biochemistry, 173, 120-125 (2017).
DOI: 10.1016/j.jinorgbio.2017.05.007
2016
Y. Asaba, S. Asayama*, and H. Kawakami*, Design of Epigenetics Control Carrier for Simultaneous Transfection of Histone Acetyltransferase with Histone Deacetylase Inhibitor to Continuous Histone Acetylation,Polymer Journal, 48, 561-564 (2016).
2015
S. Asayama*, A. Nohara, Y. Negishi, and H. Kawakami, Plasmid DNA Mono-Ion Complex Stabilized by Hydrogen Bond for In Vivo Diffusive Gene Delivery,Biomacromolecules, 16, 1226-1231 (2015).

S. Asayama*, T. Kumagai, and H. Kawakami, Screening for Methylated Poly(L-histidine) with Various Dimethylimidazolium/Methylimidazole/Imidazole Contents as DNA Carrier,Pharmaceutics, 7, 224-232 (2015).
2014
S. Asayama*, A. Nohara, Y. Negishi, and H. Kawakami, Alkylimidazolium End-Modified Poly(ethylene glycol) to Form the Mono-Ion Complex with Plasmid DNA for In Vivo Gene Delivery,Biomacromolecules, 15, 997-1001 (2014).

S. Asayama*, K. Matsuda, Y. Negishi, and H. Kawakami, Intracellular Co-Delivery of Zinc Ions and Plasmid DNA for Enhancing Gene Transfection Activity,Metallomics, 6, 82-87 (2014) (Selected for Inside Front Cover).

S. Asayama*, T. Hakamatani, and H. Kawakami, Tuning of the Methylimidazolium/Imidazole Balance in Polycations for Gene Carrier,Polymers for Advanced Technologies,25, 823-826 (2014).

R. Kubota, S. Asayama*, and H. Kawakami*, A Bioinspired Polymer-Bound Mn-Porphyrins with an Artificial Active Center of Catalase,Chemical Communications, 50, 15909-15912 (2014).
2013
S. Asayama*, K. Seno, and H. Kawakami, Synthesis of Carboxymethyl Poly(1-vinylimidazole) as a Polyampholyte for Biocompatibility,Chemistry Letters, 42, 358-360 (2013).
2012
S. Asayama*, T. Kumagai, and H. Kawakami, Synthesis and Characterization of Methylated Poly(L-histidine) to Control the Stability of its siRNA Polyion Complexes for RNAi,Bioconjugate Chemistry, 23, 1437-1442 (2012).

K. Hazama, S. Asayama*, and H. Kawakami*, Up-Regulation of Gene Expression by Transfection to Hepatocyte Spheroids,Molecular Pharmaceutics, 9, 3602-3605 (2012).

S. Asayama*, N. Hayakawa, and H. Kawakami, Design of Mn-Porphyrin/HyaluronicAcid Complexes for a Functional Antioxidant,ALA-Porphyrin Science, 1, 3-9 (2012).
2011
S. Asayama*, S. Nishinohara, and H. Kawakami, Zinc-Chelated Poly(1-vinylimidazole) and a Carbohydrate Ligand Polycation Form DNA Ternary Complexes for Gene Delivery, Bioconjugate Chemistry,22, 1864-1868 (2011).

S. Asayama*, S. Nishinohara, and H. Kawakami, Zinc-Chelated Imidazole Groups for DNA Polyion Complex Formation,Metallomics, 3, 680-682 (2011).
2010
S. Asayama*, T. Hakamatani, and H. Kawakami, Synthesis and Characterization of Alkylated Poly(1-vinylimidazole) to Control the Stability of its DNA Polyion Complexes for Gene Delivery,Bioconjugate Chemistry, 21, 646-652 (2010).
2008
S. Asayama*, A. Ogawa, H. Kawakami, and S. Nagaoka, Double-Stranded RNA Homopolymer Poly(rC)∙Poly(rG) for a New pH-Sensitive Drug Carrier,Molecular Pharmaceutics, 5, 162-164 (2008).

S. Asayama*, M. Sudo, S. Nagaoka, and H. Kawakami, Carboxymethyl Poly(L-histidine) as a New pH-Sensitive Poly- peptide to Enhance Polyplex Gene Delivery,Molecular Pharmaceutics, 5, 898-901 (2008).
2007
S. Asayama*, T. Sekine, H. Kawakami, and S. Nagaoka, Design of Aminated Poly(1-vinylimidazole) for a New pH- Sensitive Polycation to Enhance Cell-Specific Gene Delivery,Bioconjugate Chemistry, 18, 1662-1667 (2007).

S. Asayama*, H. Kato, H. Kawakami, and S. Nagaoka, Carboxymethyl Poly(L-histidine) as a New pH-Sensitive Poly- peptide at Endosomal/Lysosomal pH,Polymers for Advanced Technologies, 18, 329-333 (2007).
2006
S. Asayama*, T. Sekine, H. Kawakami, and S. Nagaoka, pH-Dependent Dissociation of Carbohydrate Ligand Polycations from DNA Ternary Complexes,Chemistry Letters, 35, 100-101 (2006)

S. Asayama*, E. Kawamura, S. Nagaoka, and H. Kawakami, Design of Manganese Porphyrin Modified with Mitochondrial Signal Peptide for a New Antioxidant,Molecular Pharmaceutics, 3, 468-470 (2006).
2005
S. Asayama*, T. Sekine, A. Hamaya, H. Kawakami, and S. Nagaoka, Poly(L-histidine) with Several Aminoethyl Groups for a New pH-Sensitive DNA Carrier, Polymers for Advanced Technologies, 16, 567-570 (2005).
2004
S. Asayama*, H. Kawakami, and S. Nagaoka, Design of the Poly(L-histidine)-Carbohydrate Conjugate for a New pH-Sensitive Drug Carrier,Polymer Advanced Technologies, 15, 439-444 (2004).

S. Asayama*, K. Mizushima, S. Nagaoka, and H. Kawakami, Design of Metalloporphyrin-Carbohydrate Conjugates for a New Superoxide Dismutase Mimic with Cellular Recognition,Bioconjugate Chemistry, 15, 1360-1363 (2004).
2003
S. Asayama*, H. Kawakami, and S. Nagaoka, Facile Chemical Modification of the Poly(L-histidine) for a New pH-Sensitive Polypeptide,Chemistry Letters, 32, 1152-1153 (2003).