　Teppei Ikeya's Homepage

ABOUT ME

Assistant Professor in Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University

　　 IKUMEN 　IKUMEN, in Japan, is currently a popular word denoting males keenly taking care of their sons or daughters, which was created by combining IKU meaning childcare in Japanese and MEN in English. Many fathers are now enthusiastic caring their babies and spending time with them, although in Japanese old custom it was virtue to dedicate all efforts to jobs of companies.

　I am a pure IKUMEN! You can imagine from the photo how much I concentrate taking care of my daughter.

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RESEARCH

Development of computational methodologies for NMR data analysis and structure calculation.

　　
■　Protein Structure determination and dynamics analysis in living cells
　　　　by in-cell NMR
　　
■　Development of torsion angle molecular dynamics simulation for NMR
　　
　　structure determination
　　
■　Development of full automatic structure calculation
　　
■　Development for peak picking methodology by machine learning

　　
[Reviewed Papers]
　　
　　
■ Ikeya, T., Jee. J. G., Shigemitsu, Y., Hamatsu, J., Mishima, M., Ito, Y.,
　　　　 Kainosho, M. & Guntert, P. Automated NMR chemical shift assignment and
　　　　 protein structure determination using exclusively NOESY spectra.
　　　　 J. Biomol. NMR., published online ahead of print (2011)
　　
■ Ikeya, T., Sasaki, A., Sakakibara, D., Shigemitsu, Y., Hamatsu, J.,
　　　　 Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T.,
　　　　 Nietlisbach, D., Walchli, M., Smith, B. O., Shirakawa, M., Guntert, P. & Ito, Y.
　　　　 NMR protein structure determination in living E. coli cells using nonlinear
　　　　 sampling. Nature Protocols 5, 1051-1060 (2010)
　　
■ Sobhanifar, S., Schneider, B., Lohr, F., Gottstein, D., Ikeya, T., Filipek, S.,
　　　　 Guntert, P., Bernhard, F. & Dotsch, V. Structural investigation of the
　　　　 C-terminal catalytic fragment of presenilin-1. Proc. Natl. Acad. Sci. USA 107,
　　　　 9644-9649 (2010)
　　
■ Coutandin, D., Lohr, F., Niesen, F. H., Ikeya, T., Weber, T. A., Schafer, B.,
　　　　 Bullock, A. N., Yang, A., Guntert, P. , Knapp, S., McKeon, F., Der Ou, H. &
　　　　 Dotsch, V. Conformational stability and activity of p73 require a second
　　　　 helix in the tetramerization domain. Cell Death Diff. 16, 1582?1589 (2009)
　　
■ Ikeya, T., Takeda, M., Yoshida, H., Terauchi, T., Jee, J., Kainosho, M. &
　　　　 Guntert, P. Automated NMR structure determination of stereo-array isotope
　　　　 labeled ubiquitin from minimal sets of spectra using the SAIL-FLYA system.
　　　　 J. Biomol. NMR. 44, 261-272 (2009)
　　
■ Sakakibara, D.*, Sasaki, A.*, Ikeya, T.*, Hamatsu, J., Hanashima, T.,
　　　　 Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., W?lchli, M., Smith,B.O.,
　　　　 Shirakawa, M., G?ntert, P. & Ito, Y. Protein structure determination in living
　　　　 cells by in-cell NMR spectroscopy. Nature 458, 102-105 (2009)
　　　　　* These authors contributed equally to this work.
　　
■ Takeda, M., Sugimori, N., Torizawa, T., Terauchi, T., Ono, A. M., Yagi, H.,
　　　　 Yamaguchi, Y., Kato, K., Ikeya, T., Jee, J., Guntert, P., Aceti, D. J., Markley,
　　　　 J.L. & Kainosho, M. Structure of the putative 32 kDa myrosinase binding
　　　　 protein from Arabidopsis (At3g16450.1) as determined by the SAIL-NMR
　　　　 method. FEBS J. 275, 5873-5884 (2008)
　　
■ Takeda, M., Chang, C. K., Ikeya, T., Guntert, P., Chang, Y. H., Hsu, Y. L.,
　　　　 Huang, T. H. & Kainosho, M. Solution structure of the C-terminal
　　　　 dimerization domain of SARS coronavirus nucleocapsid protein determined
　　　　 by the SAIL-NMR method. J. Mol. Biol. 380, 608-622 (2008)
　　
■ Takeda, M., Ikeya, T., Guntert, P. & Kainosho, M. Automated structure
　　　　 determination of proteins with the SAIL-FLYA NMR method. Nature Protocols
　　　　 2, 2896-2902 (2007)
　　
■ Ikeya, T., Terauchi, T., Guntert, P. & Kainosho, M. Evaluations of
　　　　 stereo-array isotope labeling (SAIL) patterns for automated structural
　　　　 analysis of proteins with CYANA. Magn. Reson.Chem. 44, S152-157 (2006)
　　
■ Kurashima, I.K., Ikeya, T., Senbongi, H., Tochio, H., Mikawa, T., Shibata, T.
　　　　 & Ito,Y., Heteronuclear multidimensional NMR and homology modeling
　　　　 studies of the C-terminal nucleotide-binding domain of the human
　　　　 mitochondrial ABC transporter ABCB6., J. Bio. NMR. 35 (1): 53-71 (2006)
　　
■ Isogai, Y., Ito, Y., Ikeya, T., Shiro, Y. & Ota, M., Design of Cro fold: Solution
　　　　 Structure of a Monomeric Variant of the de Novo Protein, J. Mol. Bio.,
　　　　 354(4), 801-814 (2005)
　　
■ Endo, H., Persson, P., Ikeya, T., Takagi, Y. & Watanabe, T., Molecular
　　　　 analysis of genes expressed during the calcification of the exoskeleton of
　　　　 the decapod crustacean Penaeus japonicus, in "Biomineralization:
　　　　 formation, diversity, evolution and application, Tokai University Press,
　　　　 Kanagawa,149-152 (2003)
　　
■ Ikeya, T., Persson, P., Kono, M. & Watanabe, T. The DD5 gene of the
　　　　 decapod crustacean Penaeus japonicus encodes a putative exoskeletal
　　　　 protein with a novel tandem repeat structure., Comp. Biochem. Physiol.,
　　　　 128B: 379-388. (2001)
　　
■ Persson, P., Ikeya, T. & Watanabe, T., Formation of the Calcified
　　　　 Exoskeleton in the Prawn, Penaeus japonicus. In Calcium Metabolism:
　　　　 Comparative Endocrinology. Eds Dacke C, Danks J, Flik G and Gay C.,
　　　　 BioScientifica Ltd, Bristol, 1-6. (1999)
　　
　　
[Books]
　　
　　
■ 池谷鉄兵, Peter Guntert, 甲斐荘正恒,「 NMRによる蛋白質構造決定の自動化」,
　　　　計算シミュレーションと分析データ解析(日本表面科学会　編)、148-166、丸善 (2007)
　　
■ 池谷鉄兵「データの可視化」, バイオインフォマティクスコンピューティング,
　　　　（Bryan Bergeron、清水謙多郎、中村周吾　編）, 100-110, オーム社 (2004)